The Gene Regulation Group aims to discover how faulty genes contribute to the development of heart disease. Genes holds all the information necessary for the normal functioning of cells within our body including the "blueprints" or instructions to build cells. But when genes become damaged, the information they supply can cause cells to stop working properly and lead to disease. The group is primarily interested in discovering how damaged genes lead to early atherosclerotic plaque development in blood vessels, by unravelling the molecular pathways involved. They do this by employing a host of cutting-edge technologies including gene silencing, gene array, proteomics and histology methods to define the role of newly discovered genes in human and experimental heart disease plaques.
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