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The Board of Governors is chaired by The Hon Peter McGauran and comprises a representative of the Deans of the Medical Schools of Australia, two nominees from each of the Sydney Local Health District and The University of Sydney, and leaders from the corporate sector.

The Board is responsible for the governance of the Heart Research Institute. It approves and monitors governance, strategy, budgets and scientific progress. Members are balanced to represent the corporate and scientific community. The majority of the Board positions are available to be filled via election by the members of the incorporated company, the Heart Research Institute Ltd.