Stroke occurs when the blood supply to the brain is cut off, starving brain cells of oxygen and important nutrients, resulting in impacted areas of the brain dying. The most common cause of stroke is a blood clot obstructing blood flow, known as an ischaemic stroke.
Stroke impacts almost 55,0001 Australians each year, plus their families and friends. It can occur without warning at any age, causing a range of disabilities. With a total financial cost to Australia of approximately $5 billion2 per year, the burden of stoke is not just physical. Productivity costs of $3 billion and carer costs of $222 million reflect how individuals also bear the greatest financial burden of stroke – with estimates showing family and friends wear approximately $67 million of stroke-related costs in a year.
Existing stroke treatment
Since its approval for use in 1996, there has only been a single drug available to treat ischaemic stroke (caused by blood clot). The administration of tPA to patients suffering stroke, referred to as "thrombolysis", has a range of side effects, meaning only 10 per cent of stroke sufferers are deemed eligible to receive this treatment.
This leaves 90 per cent of stroke survivors without options.
HRI's scientific breakthrough
The Thrombosis Group at HRI is developing a revolutionary new class of anti-clotting drug that could improve the quality of life for thousands of stroke sufferers, when combined with the existing stroke therapies.
Led by Professor Shaun Jackson, the group has confirmed the effectiveness of its drug in pre-clinical laboratory studies, and demonstrated the safety of its drug in healthy humans through Phase I clinical trials. Now, the group is working towards implementing Phase II Clinical trials – testing the effectiveness of its drug on stroke patients.
This means that over the next decade, healthcare professionals in around the world could have a better treatment for stroke in market.
What can you do to help?
HRI needs just AUD$2 million in funding to realise its ground-breaking research.
Additional funding will help researchers test the new drug’s effectiveness on stroke survivors, moving research into the next phase and closer to increasing stroke survivors’ quality of life. HRI has launched a Donate A Dose, a crowdfunding campaign to help get this research underway. Please donate below to help us develop the new class of clot-busing drug to treat stroke.