Dr Anna Waterhouse

PhD, BSc (Hons I)
"To succeed as a scientist, it takes hard work, dedication and a curious mind."

Dr. Waterhouse is a Group Leader at the Heart Research Institute and a Senior Lecturer at the University of Sydney. She is the recipient of an ARC Discovery Early Career Researcher Award (DECRA). Her research combines cardiovascular device engineering and biological interactions at material interfaces, aiming to understand how devices fail in order to create materials that interact with the body in a more biological way, mimicking the body's own tissue. Prior to joining the HRI she was a Postdoctoral Fellow and Research Scientist at the Wyss Institute for Biologically Inspired Engineering at Harvard University with Prof. Don Ingber. Dr Waterhouse received her PhD from the University of Sydney and the Heart Research Institute on biomimetic coronary stent coatings to treat coronary artery disease under the supervision of Prof. Tony Weiss, Assoc. Prof. Ng and Prof. Bilek.

Current Appointments

Cardiovascular Medical Devices Group Leader

Heart Research Institute

Senior Lecturer 

University of Sydney

ARC Discovery Early Career Researcher Award recipient
Dr Anna Waterhouse leads group:
Research covers areas of:

More about Dr Anna Waterhouse

Research Project Opportunities
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Creating micro-systems to study medical devices and their failure mechanisms

In order to better understand thrombosis and biofouling and develop improved materials for medical devices, we are creating innovative micro-systems to study medical device materials in the laboratory. Utilising the new facilities at Australian Institute of Nanoscale Science and Technology (AINST) at the University of Sydney, this multidisciplinary project aims to create micro-systems that mimic aspects of medical device materials and geometries. Using these micro-systems, we will study how variations in material properties and blood flow dynamics govern the initiation of biomaterial-induced thrombosis. This knowledge can ultimately be used to improve or generate new materials for use in medical devices to improve their function and patient outcomes.

Slippery surface coatings to prevent thrombosis and pathogenic biofouling of medical devices

Newly developed, super slippery, liquid-repellent surface coatings have great potential to revolutionise medical devices, imparting anti-adhesive properties to materials. Given that surface adhesion of proteins and cells is the driving factor in medical device fouling in processes such as thrombosis and pathogen adhesion in biofilm formation, this repellent surface coating is being investigated to prevent thrombosis of materials. As part of the Australian Centre for Microscopy and Microanalysis (ACMM) at the University of Sydney, the Charles Perkins Centre houses a suite of microscopes with high resolution capabilities to visualis–e biomolecule-surface interactions. In this project, we aim to elucidate the mechanism by which these liquid-surfaces are anti-adhesive to proteins, mammalian cells and bacteria, with the goal of translating this to medical devices in the clinic to prevent their failure.

Research Grants
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An in vitro model of biomaterial-induced thrombosis; Waterhouse A; Australian Research Council (ARC)/Discovery Early Career Researcher Award (DECRA), 2016
Latest Publications
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Cartwright, M., Rottman, M., Shapiro, N., Seiler, B., Lombardo, P., Gamini, N., Tomolonis, J., Watters, A., Waterhouse, A., Leslie, D., et al (2016). A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood. EBioMedicine, 9, 217-227. 

Jain, A., Graveline, A., Waterhouse, A., Vernet, A., Flaumenhaft, R., Ingber, D. (2016). A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function. Nature Communications, 7, 1-10. 

Sotiri, I., Overton, J., Waterhouse, A., Howell, C. (2016). Immobilized liquid layers: A new approach to anti-adhesion surfaces for medical applications. Experimental Biology and Medicine, 241(9), 909-918. 

Wise, S., Michael, P., Waterhouse, A., Santos, M., Filipe, E., Hung, J., Kondyurin, A., Bilek, M., Ng, M. (2015). Immobilization of bioactive plasmin reduces the thrombogenicity of metal surfaces. Colloids And Surfaces B: Biointerfaces, 136, 944-954. 

Didar TF, Cartwright MJ, Rottman M, Graveline AR, Gamini N, Watters AL, Leslie DC, Mammoto T, Rodas MJ, Kang JH, Waterhouse A, Seiler BT, Lombardo P, Qendro EI, Super M, Ingber DE.

Didar, T., Cartwright, M., Rottman, M., Graveline, A., Gamini, N., Watters, A., Leslie, D., Mammoto, T., Rodas, M., Waterhouse, A., et al (2015). Improved treatment of systemic blood infections using antibiotics with extracorporeal opsonin hemoadsorption. Biomaterials, 67, 382-392. 

Leslie, D., Waterhouse, A., Berthat, J., Valentin, T., Watters, A., Jain, A., Kim, P., Hatton, B., Nedder, A., Donovan, K., et al (2014). A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling. Nature Biotechnology, 32(11), 1134-1140. 

For a full list of Dr Anna Waterhouse's publications, visit pubmed.gov

2016     Postdoctoral Fellow and Research Scientist, Harvard University, Wyss Institute for Biologically Inspired Engineering
2011     PhD, Bioengineering and Biomedical Engineering, University of Sydney
2005     Honours (1st Class) Cell Biology, University of Manchester