Biography

Dr Mike Wu received his PhD in 2013 from the School of Biomedical Sciences at the University of Queensland. He joined Professor Shaun Jackson’s laboratory as a post-doctoral researcher in 2014 at the Australian Centre for Blood Diseases in Melbourne. In 2015, the group relocated to HRI in Sydney, where he continues his role.

His research focuses on understanding the mechanisms of blood clotting in relation to thrombosis and inflammation, post ischemia-reperfusion injury, and investigating new anti-thrombotic drugs for vascular diseases, including ischemia-reperfusion injury.

Grants and awards

2017 University of Sydney Kickstart Grant

2016 Australian Vascular Biology Society Travel Award

Collaborations

2017 – 2020: Prof. Richard Payne (School of Chemistry, USyd), funded under NHMRC Project Grant 1120941

Current projects

Developing a novel preclinical ischaemic stroke model

Understanding the mechanisms leading to microvascular dysfunction and poor cerebral perfusion in stroke

Developing safer anti-clotting agents derived from “Mother Nature”

The powerful enzyme Thrombin is by far the most robust activator of platelets and blood clotting (coagulation) in both physiological haemostasis and pathological thrombotic response.

Biomechanical sensing and blood clot formation: Solving a sticky clotting problem in diabetes

The leading cause of death in people with diabetes is cardiovascular disease, with up to 70% of deaths relating to the development of blood clots supplying the heart (heart attack) or brain (ischemic stroke).

Developing novel approaches to the treatment of ischaemic stroke

The development of a blood clot in the cerebral circulation (ischaemic stroke) is the third most common cause of death and the most common cause of adult disability globally.

Platelet death as an important regulator of blood clot formation

Antithrombotic therapies, which primarily consist of antiplatelet and anticoagulant agents, have become the cornerstone therapies for a wide variety of cardiovascular diseases.

Projects

Developing a novel preclinical ischaemic stroke model

Understanding the mechanisms leading to microvascular dysfunction and poor cerebral perfusion in stroke

Developing safer anti-clotting agents derived from “Mother Nature”

Biomechanical sensing and blood clot formation: Solving a sticky clotting problem in diabetes

Dr Mike Wu

Biography

Grants and awards

Collaborations

Current projects

Developing a novel preclinical ischaemic stroke model

Understanding the mechanisms leading to microvascular dysfunction and poor cerebral perfusion in stroke

Developing safer anti-clotting agents derived from “Mother Nature”

Biomechanical sensing and blood clot formation: Solving a sticky clotting problem in diabetes

Developing novel approaches to the treatment of ischaemic stroke

Platelet death as an important regulator of blood clot formation

Projects

Developing a novel preclinical ischaemic stroke model

Understanding the mechanisms leading to microvascular dysfunction and poor cerebral perfusion in stroke

Developing safer anti-clotting agents derived from “Mother Nature”

Biomechanical sensing and blood clot formation: Solving a sticky clotting problem in diabetes

Developing novel approaches to the treatment of ischaemic stroke

Platelet death as an important regulator of blood clot formation

“Bad Blood”: Unravelling the link between gut ischemia and remote organ injury