“We urgently need models that accurately replicate this terrible disease, to increase our fundamental understanding of the key mechanisms driving it. With this knowledge, we could open a pathway to discovering ways to treat HFpEF and thus save countless lives.”
The review, under lead researcher Gabrielle Fusco-Allison, examines historical models of heart failure that could be applied to advance understanding of HFpEF. The review also identifies a novel model that provides unparalleled insights into the pathology of HFpEF, discusses recent technological developments that have improved this model further, and explores ways in which it could accelerate novel therapeutic discovery.
