We work with exciting new classes of biomaterials, including naturally derived proteins and polymers and the latest in synthetically produced plasma surfaces and products. We aim to engineer and optimise these materials to be therapeutically useful in the treatment of vascular disease and more broadly in tissue repair.
The materials currently available for vascular repair are fundamentally incompatible with the tissues they seek to repair. Metal alloys like stainless steel, and the same plastics used in Goretex jackets and drinking straws are in wide use, relying on technology that has not evolved considerably for several decades.
Discovery of new materials that could be used clinically would have a significant impact on the lives of patients.
Filipe, E., et al. Rapid endothelialization of off-the-shelf small diameter silk vascular grafts. JACC: Basic to Trans Sci, 2018. 3:38-53.
Tan, R., et al. Bioactive materials facilitating targeted local modulation of inflammation. JACC: Basic to Trans Sci, 2019. 4:56-71.
Tan, R.P., et al. Non-invasive tracking of injected bone marrow mononuclear cells to injury and implanted biomaterials. Acta Biomater, 2017 53:378–388.
Santos, M., et al. Plasma synthesis of nanocarriers for linker-free, spontaneous immobilization of bioactive cargo. ACS Applied Nano Materials. 2018. 1: 580-594.
Santos, M., et al. Mechanically robust plasma-activated interfaces optimized for vascular stent applications. ACS Appl Mater Interfaces, 2016, 8 (15), pp 9635–9650.