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Biography

Dr Polina Nedoboy received her PhD in 2014 from the Heart Research Institute, The University of Sydney. Her PhD project provided novel insight as to how MPO-derived oxidants may be implicated in damaging critical tissue targets and which antioxidant enzyme systems are involved in the protection against this damage. Following her PhD studies, Polina joined the High Blood Pressure Research group at the HRI as a postdoctoral researcher and worked under the guidance of Prof Paul Pilowsky in the field of systems neuroscience and physiology until his retirement in the late 2018.

In 2019, Polina continued her research in the newly established Cardiovascular Neuroscience unit at the HRI. She has extensive experience in in vivo electrophysiology (rodent models of sleep apnoea, epilepsy, hypoglycaemia, and myocardial infarction), fluorescence microscopy, immunohistochemistry and in situ hybridisation, mammalian (including hybridoma) cell culture, analytical chemistry techniques, ELISA and Western blotting, flow cytometry, enzyme activity and kinetic assays. Her current work focuses on the study of brain circuitry involved in glucose homeostasis in different pathological conditions, such as diabetes and sleep apnoea, and how dysregulation of these neural networks affects cardiovascular function.

To succeed as a scientist, it takes an important and interesting question, an open mind, and a supportive, collaborative team and community.”

Projects

Low carbohydrate (ketogenic) diet in type 1 diabetes: do ketones protect the brain from adverse effects of hypoglycaemia?