Cardiometabolic Disease.

Our ultimate goal is to reduce the burden of cardiovascular disease. We aim to do this by discovering new targets for treatment, developing new treatments,

and finding better markers and predictors of disease so that we can apply therapies earlier to improve patient outcomes.

What impact will this research have? 

Obesity-related diseases are the major health challenges of our generation. Obesity-driven type 2 diabetes has dramatically increased in prevalence in Australia and other Western countries in the last few decades. Alarmingly, in the last decade alone, highly populous developing countries like India and China have seen type 2 diabetes reach epidemic proportions. In fact, the WHO described the increase of type 2 diabetes in China as “explosive”, where 114 million people have type 2 diabetes and 500 million people (almost 50% of all adults) have prediabetes.

There is an urgent global need for better ways to detect and treat type 2 diabetes. One of the cornerstones of treatment of type 2 diabetes is early intervention. Our discovery of a new molecule that independently predicts diabetes 12 years before diagnosis has huge clinical potential to facilitate intervention well before overt onset of diabetes and its attendant complications such as cardiovascular disease. Furthermore, by detailing the entire pathway controlling levels of this molecule, we can now determine if this pathway can treat type 2 diabetes.

Dr John O'Sullivan
Research group led by:
Research covers areas of:
What’s new in the lab?

Meet the team: Richard Tan

“A career in research really gives you a sense of purpose and drive. While it can be a long and difficult path, every day you can feel satisfied that the work you do is for the greater good. And that in itself is one of the most rewarding experiences,” says Richard Tan, PhD candidate with the Applied Materials Group at HRI.

Current team update

Dr Anna Waterhouse invited to speak at Joint Annual Scientific Meeting in Hobart. 

Dec 05, 2016

Help fund vital research into heart disease

Select your donation details
You can choose between donating once or monthly.
Please enter or select your donation amount.
Invest in a future free from cardiovascular disease.
Your donation will allow great science to flourish.
All donations are tax deductible.