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This study aims to investigate colchicine’s effects on both plaque development and regression.

In this study we are utilising a well-established lab model of atherosclerosis. By employing this model, we are able to determine whether colchicine treatment can affect the contents of atherosclerotic plaque by modulating its cellular components and subsequently reducing overall plaque burden.

This study consists of two models: a treatment regression model, in which we will assess whether colchicine can reverse pre-formed plaque build-up, and a prevention model, in which we will assess whether colchicine can prevent plaque development.

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