Atherosclerosis and Vascular Remodeling.

Our mission is to identify and gain insights from the genetic and molecular pathways involved in cardiovascular disorders

and exploit these pathways to provide better therapeutic options to eradicate cardiovascular disease.

The main objective of our research program is to broaden our understanding of the cellular and molecular mechanisms involved in blood vessel wall patterning and define the role of these pathways in vascular abnormalities and complications, and then link these insights to translational research to improve the prevention and treatment of human cardiovascular disease. To this end, we employ a unique blending of mouse models, cultured cells as well as human samples, that are aimed at unveiling the pathogenesis of cardiovascular diseases. Our ultimate goal is to prevent and reverse vascular disease to prevent heart attack and stroke.

What impact will this research have?

Currently available cardiovascular therapies are not universally effective and do not reverse the vascular disease completely, therefore vascular diseases place a heavy burden on the health care system. Our ultimate mission is to identify the factors and signalling mechanisms that may provide better therapeutic options to eradicate cardiovascular disease.

Dr Ashish Misra
Research group led by:
Research covers areas of:
What’s new in the lab?

Mentoring the next generation of scientists

Recently, ten bright young researchers from New Zealand took part in a summer scholarship at the HRI to get hands-on experience in our world-class laboratory facilities and to be mentored by leaders in the cardiovascular disease research field. They share their experiences here.
Current team update

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