The main objective of our research program is to broaden our understanding of the cellular and molecular mechanisms involved in blood vessel wall patterning and define the role of these pathways in vascular abnormalities and complications, and then link these insights to translational research to improve the prevention and treatment of human cardiovascular disease. To this end, we employ a unique blending of mouse models, cultured cells as well as human samples, that are aimed at unveiling the pathogenesis of cardiovascular diseases. Our ultimate goal is to prevent and reverse vascular disease to prevent heart attack and stroke.
Currently available cardiovascular therapies are not universally effective and do not reverse the vascular disease completely, therefore vascular diseases place a heavy burden on the health care system. Our ultimate mission is to identify the factors and signalling mechanisms that may provide better therapeutic options to eradicate cardiovascular disease.
Every day, 23 Australians die from a heart attack. Every year, roughly 55,000 suffer a life-threatening cardiovascular emergency. Like so many, Greg Bridgman never thought it would happen to him.