Associate Professor Sanjay Patel

MBBS, PhD, FRACP
“Success in research requires diligence, patience and humility”

Associate Prof Patel (MBBS [Hons 1 Syd] PhD FRACP FCSANZ) is a Staff Interventional Cardiologist and Director of the Cardiac Catheterisation Laboratory, Royal Prince Alfred Hospital; Group Leader at the Heart Research Institute, Sydney and Clinical Associate Professor at the Sydney Medical School. Assoc Prof Patel was awarded his MBBS (Hons 1) from the University of Sydney in 2000; completed his advanced cardiology training at Royal Prince Alfred Hospital in 2006; his doctoral studies in 2009, supported by a NHF postgraduate research scholarship; and his postdoctoral studies at Stanford University, while simultaneously training in interventional cardiology at Stanford University Medical Centre (2009–2010), supported by an NHMRC CJ Martin Overseas Fellowship Grant.

Current Appointments

Cell Therapeutics Group Leader

Heart Research Institute

Clinical Associate Professor

Sydney Medical School, The University of Sydney

Director

Cardiac Catheterisation Laboratory, Royal Prince Alfred Hospital

Interventional Cardiologist

Royal Prince Alfred Hospital

Associate Professor Sanjay Patel leads group:
Research covers areas of:
Contact Associate Professor Sanjay Patel

More about Dr. Sanjay Patel

Research Project Opportunities
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Cardiovascular regeneration using induced pluripotent stem cells

Induced pluripotent stem cells (iPSCs) are a novel stem cell type that holds great promise in augmenting cardiovascular regeneration.

Differentiation of iPSCs to iPSC-ECs: The reprogrammed cells will be characterised in vitro to confirm their pluripotentiality.To initiate differentiation, the iPS cells will be cultured in non-adhesive dishes to form embryoid body aggregates that can spontaneously differentiate.

The cells are then dissociated and purified for the EC-specific markers vascular endothelial (VE)-cadherin and PECAM-1 by FACS. The EC phenotype of the iPS-derived ECs is confirmed by gene expression assays. Our group also has experience in generating an EC-specific reporter construct for purification and bioluminescence tracking of ECs. These novel techniques therefore allow for dynamic tracking of ECs in vitro and in vivo.

Assessment of the function of iPS-derived ECs in vitro: Established methods will be employed to characterise the function of these cells, including assays for cell proliferation, cell migration, and tube formation in matrigel. We will further assess incorporation of iPS-ECs into biosynthetic hydrogels to form functional vascularised tissue.

In vivo assessment of iPS-EC function: The mouse hindlimb ischaemia model has been well characterised in our laboratory, and the effects of these cells in promoting expansion of the microvasculature and tissue perfusion will be assessed. Moreover, the ability of iPSC-ECs to promote wound healing in
a mouse tissue injury model will be evaluated.

Featured Publication
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Martinez G, Celermajer DS, Patel S. The NLRP3 Inflammasome and the emerging role of colchicine to inhibit atherosclerosis-associated inflammation. Atherosclerosis. 2017. In press.
Vaidya K, Arnott C, Martínez G, Ng B, McCormack S, Sullivan D, Celermajer D, Patel S. Colchicine Therapy and Plaque Stabilisation in Acute Coronary Syndrome Patients – A CT Coronary Angiography Study. JACC Cardiovasc Imaging. 2017. Oct 14. pii: S1936-878X(17)30791-X
Robertson, S, Martinez, G, Payet, C, Barraclough, J, Celermajer, D, Bursill C, Patel S. Colchicine Therapy in Patients Presenting with an Acute Coronary Syndrome acts on Caspase-1 to Suppress NLRP3 Inflammasome Monocyte Activation. Clin Sci (Lond). 2016 Apr 21. pii: CS20160090
Martinez G, Robertson S, Barraclough J, Mallat Z, Bursill C, Celermajer D, Patel S. Colchicine acutely suppresses local cardiac production of inflammatory cytokines in patients with an acute coronary syndrome. Journal of the American Heart Association. 2015. 4: e002128
Martínez GJ, Barraclough JY, Nakhla S, Kienzle V, Robertson S, Mallat Z, Celermajer DS, Patel S. Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndrome patients. Biosci Rep. 2017. 37(1). pii: BSR20160430
Choteau S, Cuesta Torres LF, Barraclough J, Elder A, Martínez G, Chen Fan W, Shrestha S, Ong K, Barter P, Celermajer D, Rye K-A, Patel S*, Tabet F* *equal contribution. Transcoronary Gradients of HDL-Associated MicroRNAs in Unstable Coronary Artery Disease. Int J Cardiol. 2017. In press
Martinez G, Bailey B, Celermajer D, Patel S. A safe and easy technique to sample the coronary sinus - facilitating a closer look at cardiac disease. International Journal of Cardiology. 2014. 176:1321-2
Xia Q, Kahramanian A, Arnott C, Bao S, Patel S. Characterisation of novel cytokines in human atherosclerotic plaque. International Journal of Cardiology. 2014. 176:1167-9
Arnott C, Punia-Moorthy G, Tan J, Sadeghipour S, Bursill C, Patel S. The Vascular Endothelial Growth Factor Inhibitors Ranibizumab and Aflibercept Markedly Increase Expression of Atherosclerosis-associated Inflammatory Mediators on Vascular Endothelial Cells. PLOS One. 2016. 11: e0150688.
Clayton Z, Yuen G, Sadeghipour S, Hywood J, Wong J, Huang N, Bao S, Cooke J, Patel S. A comparison of the pro-angiogenic potential of human induced pluripotent stem cell derived endothelial cells and induced endothelial cells in a murine model of peripheral arterial disease. Int J Cardiol. 2017; 234:81-89
Current Research Grants
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2017-2019     NSW Early Mid Career Fellowship
2016-2018     Ramaciotti Health Investment Grant
2016     Sydney University Bridging Fellowship
2015     IMPACT Grant
2014-    Industry Grant
2014-2015    Sydney University Medical Foundation
2013     Industry Grant
2013-2016     NHMRC Early Career Fellowship
Awards for Research
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2013     Medical School Foundation Grant
2012     Fellow of the Cardiac Society of Australia and New Zealand
2011     Pfizer Cardiovascular Research Grant, Project: “Immunomodulatory Effects of T Regulatory Cells in Atherosclerosis”
2010     Overseas Biomedical Fellowship, National Health and Medical Research Council of Australia, Project: “The Use of Induced Pluripotential Cells to Augment In Vivo Angiogenesis”
2009     Bushell Travelling Fellowship, Royal Australasian College of Physicians
2008     Travel Grant to attend annual meeting, Cardiac Society of Australia and New Zealand
2008     Finalist Young Investigator Award Clinical Section (Ralph Reader Prize), Cardiac Society of Australia and New Zealand
2008     Young Investigator Award (Patron’s Prize), Royal Prince Alfred Hospital
2008     Pfizer Major Cardiovascular Lipid Travel Grant
2008     Arteriosclerosis Thrombosis Vascular Biology Merit Award for Young Investigators
2008     Travel Grant to attend American Heart Meeting, Cardiac Society of Australia and New Zealand
2008     Travel Grant to attend American Heart Meeting, National Heart Foundation of Australia
2008     The RPA Cardiologist’s Award for the Best Clinical Science Paper by a Heart Research Institute Scientist, Heart Research Institute
2007     Travel Grant to attend American Heart Meeting, National Heart Foundation of Australia 
2006     Fellow of the Royal Australasian College of Physicians
2005     Postgraduate Research Scholarship, National Heart Foundation of Australia
2009     University of Sydney, Doctor of Philosophy, “The Anti-Inflammatory Effects of High Density Lipoproteins in Atherosclerosis”
2008     United States Medical Licensing Examination Part 1, Part II Clinical Knowledge, Part II Clinical Skills (ECFMG certified 0-634-591-2)
2003     Passed FRACP Written and Clinical Examination (1st attempt)
1999     University of Sydney, Bachelor of Medicine Bachelor of Surgery, First Class Honours, Distinctions in Final Year Medicine and Surgery
 
Professional Activities
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Community Engagement

Associate Prof Patel has received extensive national media coverage (radio, Sydney Morning Herald, web) regarding his work on colchicine in coronary disease patients. He regularly engages with the Australian Indian Medical Society. He is an advocate for women in the workplace, through his involvement in the Heart Research Institute Diversity Council and NHF Male Champions for Change Program. He also supports refugee health through involvement with the Doctors for Refugees program.

Professional and peer-review involvement

Faculty member of Coronary Physiology and Imaging Masterclass Program (Sydney 2013, 2014). Assessor for NHMRC project grants (2010-). Frequent reviewer for major international cardiovascular journals (International Journal of Cardiology, American Journal of Cardiology, Catheterization and Cardiovascular Interventions, Heart, Lung and Circulation, Scientific Reports). Director, cardiac catheterisation laboratory and CT coronary angiography program, RPAH.

Teaching

3 current PhD students, 1 completed PhD student, 1 MPhil student (completed), 1 Sydney Medical School Summer Research students and 5 MD students, 1 current research assistant. Regular thesis examiner for PhD candidates. Medical student teaching for over 15 years (bedside tutorials, problem based learning sessions and lecture series). Basic physician trainee teaching (bedside tutorials, lectures, examination preparation, local examiner).

Collaborations
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Drs Mary Kavurma and Steve Wise (Group Leaders, HRI), A/Prof David Sullivan (Head, Clinical Biochemistry, RPAH); Prof Sharon Naismith (Leonard P Ullman Chair in Psychology, Charles Perkins Centre); Prof Kerry-Ann Rye (Centre for Vascular Research, UNSW); Prof Gemma Figtree (Kolling Institute, USyd); Prof Leonard Kritharides (ANZAC institute, Usyd); Prof Graham Hillis (Royal Perth Hospital), Prof John Cooke (Director, Center for Cardiovascular Regeneration, Houston Methodist DeBakey Heart and Vascular Center); Prof Ziad Mallat (BHF, Professor of Cardiology, Cambridge UK), A/Prof Gonzalo Martinez (Santiago, Chile), Prof David Newby (University of Edinburgh)
Media Appearances
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2016    National 9 news, coronary bioresorbable scaffolds, 2017, Channel 7 nightly news, colchicine