Our objective
Our mission is to investigates the role of immune cells in cardiovascular diseases, including atherosclerosis, peripheral artery disease (PAD), and heart failure, with a particular focus on the cellular and molecular pathways that regulate inflammation, vascular injury, and tissue repair. The research examines how specific immune cell subsets—particularly myeloid and lymphoid populations—drive disease progression or, conversely, promote resolution and healing. We integrate human tissue analysis with mechanistic studies in preclinical models to define the phenotype, function, and localisation of immune cells within diseased vessels and myocardium. These insights allow us to dissect causative mechanisms and test new therapeutic concepts
Our impact
Our research aims to design and evaluate novel immunotherapies that precisely modulate immune responses, reduce vascular inflammation, enhance tissue repair, and prevent adverse cardiac events. By bridging fundamental immunology with translational research, we seek to advance the understanding of immune–vascular interactions and deliver targeted strategies that improve cardiovascular health and patient outcomes.
Selected publications
Cartland SP et al. The generation of stable microvessels in ischemia is mediated by endothelial cell derived TRAIL. Sci Adv. 2024 Oct 4;10(40):eadn8760.
Cartland SP, et al. Sex, Endothelial Cell Functions, and Peripheral Artery Disease. Int J Mol Sci. 2023 Dec 13;24(24):17439.
Kelland E, et al. The Prognostic, Diagnostic, and Therapeutic Potential of TRAIL Signalling in Cardiovascular Diseases. Int J Mol Sci. 2023 Apr 4;24(7):6725.
Cartland SP, et al. "Western Diet" promotes symptoms of hepatic steatosis in spontaneously hypertensive rats. Int J Exp Pathol. 2020 Oct;101(5):152-161.
Cartland SP, et al. Vascular transcriptome landscape of Trail-/- mice: Implications and therapeutic strategies for diabetic vascular disease. FASEB J. 2020 Jul;34(7):9547-9562.
Cartland SP et al. TRAIL-Expressing Monocyte/Macrophages Are Critical for Reducing Inflammation and Atherosclerosis. iScience. 2019 Feb 22;12:41-52.