The Vascular Complications Group focuses on understanding the pathogenesis of atherosclerosis and cardiovascular disease (CVD). We use multiple models, genetic manipulation, biochemical and molecular biology tools to dissect how blood vessels become dysregulated, with particular emphasis on changes to transcriptional regulation, vascular cell adaptation and function, under normal and abnormal settings in the blood vessel wall. Our recent work has focused on identifying protective mechanism(s) of specific genes, which have opened new opportunities for developing novel therapeutic interventions. We also ask critical questions underlying pathogenesis of obesity, diabetes and kidney disease, which are complications of CVD.
Every day, 23 Australians die from a heart attack. Every year, roughly 55,000 suffer a life-threatening cardiovascular emergency. Like so many, Greg Bridgman never thought it would happen to him.