Our mission is to understand fundamental mechanisms in molecular and cellular biology leading to cardiovascular diseases.
The end goal of our studies is to develop more effective treatments for the debilitating conditions associated with vascular complications.
What impact will this research have?
The Vascular Complications Group focuses on understanding the pathogenesis of atherosclerosis and cardiovascular disease (CVD). We use multiple models, genetic manipulation, biochemical and molecular biology tools to dissect how blood vessels become dysregulated, with particular emphasis on changes to transcriptional regulation, vascular cell adaptation and function, under normal and abnormal settings in the blood vessel wall. Our recent work has focused on identifying protective mechanism(s) of specific genes, which have opened new opportunities for developing novel therapeutic interventions. We also ask critical questions underlying pathogenesis of obesity, diabetes and kidney disease, which are complications of CVD.