Research undertaken within our Group is focused on determining the mechanisms underlying clot formation in healthy individuals; applying this knowledge to better understand the mechanisms leading to platelet hyperactivity and pathological blood clot formation; and ultimately development of safer and more effective therapies to treat cardiovascular diseases, including heart attack, stroke, diabetes and the metabolic syndrome.
Ju L, et al. Compression force sensing regulates integrin α(IIb)β(3) adhesive function on diabetic platelets. Nat Commun. 2018 Mar 14;9(1):1087.
Yuan Y, et al. Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia. Sci Transl Med. 2017 Sep 27;9(409).
Schoenwaelder SM, et al. 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nat Commun. 2016 Sep 27;7:12862.
Nesbitt WS, et al. A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat Med. 2009 Jun;15(6):665-73.
Jackson SP, et al. PI 3-kinase p110beta: a new target for antithrombotic therapy. Nat Med. 2005 May;11(5):507-14. Epub 2005 Apr 17.