What is Atherosclerosis?

Atherosclerosis (ath-er-o-skler-O-sis) is a disease in which plaques that are made up of fat, cholesterol, calcium and other substances, build up in artery walls. Over time, the plaques harden, narrow the opening of the arteries and restrict the blood flow.
 
When these fatty plaques rupture (break open), they form a thrombus (blood clot) that can further limit, or even block the flow of oxygen-rich blood to organs and other parts of the body.

Atherosclerosis can occur in arteries anywhere in the body but is most serious when it leads to a reduced or blocked blood supply to the heart or to the brain. If it occurs in one of the two main coronary arteries that supply blood to the heart this results in a heart attack. When thrombosis occurs in one of the arteries to the brain, it causes a stroke.

 

At what age does atherosclerosis occur?

Atherosclerosis is a complex process, often starting in childhood and progressing with age. Our latest research has shown that the origins of heart disease and vessel disease can begin even earlier – in the foetus. Atherosclerosis progresses as we age and often shows no symptoms until middle or older age. Detecting heart and blood vessel problems at an early stage and designing interventions to treat abnormalities, has the potential to save hundreds of thousands of lives each year.

Risk factors for atherosclerosis

90 per cent of Australians have one modifiable risk factor for heart disease. The major modifiable risk factors include smoking, high blood pressure, high blood cholesterol, insufficient physical activity, obesity, diabetes, poor nutrition, and excessive intake of alcohol. Other risk factors that are beyond our control include age, gender, family history and ethnicity.

What causes atherosclerosis?

Arteries are blood vessels that carry blood from the heart throughout the body. They're lined by a thin layer called the endothelium, a layer of cells that keeps the inside of arteries smooth, allowing blood to flow easily.
 
Atherosclerosis starts when the endothelium becomes damaged - usually caused by risk factors such as high blood pressure, smoking, or high cholesterol. When the endothelium is damaged, LDL or ‘bad’ cholesterol begins to accumulate in the artery wall. To combat this, the body sends macrophage - a type of white blood cell - to clean up the cholesterol. Sometimes the cells get stuck at the affected site. Over time this results in plaque build up, made up of bad cholesterol and macrophage white blood cells.
 
As atherosclerosis progresses, the plaque gets bigger and, when it gets big enough, it can create a blockage.

At the Heart Research Institute, we’re trying to understand how atherosclerosis develops and to find innovative ways of preventing, detecting and treating cardiovascular diseases that result.

By understanding the causes of atherosclerosis (diabetes, cholesterol, smoking, high blood pressure and family history) we can better improve human health.

Heart research costs millions. No research costs more.

Latest news from our research labs

Neutrophils in acute coronary syndrome

HRI researchers Dr Rahul Kurup and Associate Professor Sanjay Patel from the Cell Therapeutics Group recently published a review of the role of neutrophils in acute coronary syndrome. With abundant data demonstrating this role, this presents opportunities to develop novel diagnostic and prognostic biomarkers and therapeutic agents that specifically target neutrophils.
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How to prevent injury from sport and exercise

Regular physical activity is an essential part of a healthy lifestyle, protecting us from conditions such as heart disease, obesity, type 2 diabetes, depression and some cancers. Sport and exercise are great ways to accumulate regular physical activity, but what about when they do us harm?
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Scientific minds coming together

HRI researchers Dr Mary Kavurma, Associate Professor Simone Schoenwaelder, Dr Amelia Tomkins and Bradley Tucker attended the ANZMS and AVBS Conference 2017 to share and discuss the latest research in the field.
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