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Find out about cardiovascular disease and atherosclerosis, its main cause

Cardiovascular disease (CVD) refers to all the diseases of the heart and circulation, including coronary heart disease, atrial fibrillation, heart attack, congenital heart disease and stroke.

There is no one cause of cardiovascular disease (CVD), but there are several factors that increase your risk – some that can be changed, and some that cannot.

Learn more about the latest statistics and facts related to cardiovascular disease in Australia.

HRI scientists and collaborators have reviewed colchicine and its potential as a treatment for cardiovascular disease, in a paper published in Heart, Lung and Circulation.

The Heart Research Institute (HRI) is conducting a collaborative research project with the University of Cambridge to investigate new pathways to treat cardiovascular disease.

HRI is using innovative fluxomics technology to identify and explore the cell molecular fingerprint unique to each person's cardiovascular disease, with the goal of personalised medicine.

Atherosclerosis is the main underlying cause of cardiovascular disease.

Research shows bilirubin, formerly viewed as only a toxic waste product in the body, could decrease the risk of cardiovascular disease.

Peripheral artery disease (PAD) is a type of cardiovascular disease in which the narrowing of arteries results in reduced blood flow to a body part outside of the heart or brain.

Notch has been comprehensively studied as a conciliator of cell-to-cell communication that mediates cell fate decisions of progenitors.

Diabetes is a condition in which the body cannot maintain healthy blood glucose levels. People living with type 2 diabetes are over twice as likely to develop cardiovascular disease.

Coronary heart disease, also known as coronary artery disease, is a common condition where the major blood vessels to the heart become blocked and narrowed.

Heart and cardiovascular conditions can be life-changing. Understand the impact of these common conditions, and find out what you can do about them.

A cardiac arrest is when the heart suddenly stops beating. It is a medical emergency and can be fatal without immediate treatment.

Heart disease and heart attacks are often associated with older men, but women are just as affected. It is important to be aware of the unique warning signs and risks that women experience.

Want to be proactive and learn what a Heart Health Check is?

Thrombosis is when a blood clot (thrombus) forms inside a blood vessel, potentially blocking the flow of blood through the circulatory system and causing serious health issues.

Acute coronary syndrome (ACS) is an umbrella term for situations where blood supply to the heart is blocked.

A heart attack occurs when the heart is deprived of oxygen due to a blockage in one of the coronary arteries that supplies blood to the heart.

Preeclampsia is a serious condition where high blood pressure develops during pregnancy, affecting both the mother and unborn baby.

Discover the key distinctions between cardiac arrest and heart attack. Learn about signs and symptoms, and how to react in each situation.

An irregular or abnormal heartbeat (arrhythmia) is when the heart rhythm is not steady.

Heart failure is when the heart does not work as well as it should in pumping blood and oxygen around the body, causing extra fluid to build up in the body.

A heart attack is a critical event. Know the symptoms and warning signs of heart attack in women so that you can seek emergency help immediately if you suspect a heart attack.

Wondering if you have aortic stenosis? Its symptoms vary from mild to severe. Get the facts now.

Blood clotting is a natural process that occurs to prevent excessive bleeding. However, blood clots can also form on the inside of blood vessels.

Atherosclerotic plaque is composed of fat, cholesterol, calcium and inflammatory cells that build up on the inside of the body’s arteries.

A stroke occurs when the brain does not get the blood supply that it needs.

Atrial fibrillation (AF) is a type of abnormal heart rhythm where the heart beats irregularly – it may be rapid or slow.

Congenital heart disease is a general term for problems with the heart’s structure that are present from birth. It is the most common type of birth defect.

HRI’s Dr Xuyu Liu is researching how healthy heart diets that contain ‘natural products’ can give rise to new treatments for thrombosis.

Want to check your blood pressure? Follow these five simple steps.

Discover the link between alcohol and high blood pressure. Explore the effects of alcohol on the body and learn how to manage your blood pressure for better health.

HRI scientists have discovered people who smoke and also have sleep apnoea - known as the silent killer - are putting themselves in even greater danger of future health complications.

Collaboration is essential to advancing medical research, so HRI are delighted that Drs Anna Waterhouse and John O’Sullivan and their multiple research collaborations are featured by the Charles Perkins Centre, The University of Sydney.

Our mission is to repurpose existing drugs for next-generation cardiovascular disease therapy.

You can help us fight cardiovascular disease, the world's number one killer.

Helping to revolutionise treatment for cardiovascular disease.

Our mission is to investigate the pathophysiological aspects of cardiovascular diseases and the development of tissue engineering solutions for regeneration.

High blood pressure is a major risk factor for cardiovascular disease 

My gift will fund life-saving research into high blood pressure and cardiovascular disease

Our internationally regarded group leaders each research a different aspect of cardiovascular disease.

The Heart Research Institute, in partnership with major NSW hospitals, universities, and other research institutions, is striving to unravel the deadly link between the coronavirus (COVID-19) and cardiovascular disease.

High cholesterol levels can increase the risk of cardiovascular disease.

You have made a true difference in the fight against cardiovascular disease.

HRI researchers have been awarded an outstanding four grants under the NSW Cardiovascular Research Capacity Program.

Every three hours, one Australian has a limb amputated due to cardiovascular disease.

The NSW Government has backed a bold new plan to become the premier state for heart disease with a $150 million funding package to fight the resurgence of the deadly condition.

Dr James Nadel has published a literature review in Cardiovascular Research which explores the role of myeloperoxidase (MPO) in cardiovascular disease.

You can help us fight cardiovascular disease, the world's number one killer.

Discover how high cholesterol levels can increase the risk of cardiovascular disease.

Advance your scientific career and be mentored by world leaders in cardiovascular disease research.

Research shows that insoluble fibre – particularly from cereal grains and vegetables – has the best effect on reducing the risk of cardiovascular and coronary heart disease.

Cardiovascular disease is the biggest killer in the world, but does the funding for research to find better treatments and cures match the overall burden of the disease?

The Vascular Complications Group is working on a new treatment to prevent limb amputation due to cardiovascular disease.

HRI research groups are using innovative methods to reduce the burden of cardiovascular disease.

Recent HRI research has validated the metabolic pathways that link dietary components with the risk of developing cardiovascular disease.

Dr Mary Kavurma has been awarded an Australian Cardiovascular Alliance Research Catalyst Grant for her research into peripheral artery disease.

In March, HRI celebrated 30 years of groundbreaking research and new discoveries that have contributed to an improved understanding of cardiovascular disease.

Find out how fluxomics, an emerging technology, will help bring us one step closer to personalised treatments for cardiovascular disease.

The HRI Atherosclerosis and Vascular Remodelling Group has published a paper on how cardiovascular diseases are linked to clonal expansion in JACC: Basic to Translational Science.

Even a mild case of COVID can increase the long-term risks of serious cardiovascular diseases such as stroke, heart attack and heart failure.

HRI is delighted to announce the award of three grants funded by HRI donors to support research into cardiovascular disease – the world’s biggest killer.

Antithrombotic therapies, which primarily consist of antiplatelet and anticoagulant agents, have become the cornerstone therapies for a wide variety of cardiovascular diseases.

Atherosclerosis is an inflammatory condition and the main cause of cardiovascular disease, initiated by retention of cholesterol in the vessel wall.

The Heart Research Institute (HRI) is calling on public donations as part of their end of year Christmas appeal to help fund their cutting-edge research to fight cardiovascular disease.

The HRI’s annual Illuminate event recognises the achievements of some of our best and brightest early career researchers in their work to fight cardiovascular disease.

Our mission is to investigate what goes wrong in the brain to result in the development of cardiovascular disease, by focusing on the neurocircuitry within autonomic centres of the brain.

Our mission is to identify and explore the cellular changes that are unique to each individual’s cardiovascular disease, with the ultimate goal of personalised treatment.

HRI's Dr Sergey Tumanov has been awarded a prestigious grant by The Ian Potter Foundation to help establish Australia’s first Fluxomics Centre devoted to cardiovascular disease.

High blood pressure (hypertension) is cause for concern as it can damage the arteries over the long term and increase the risk of cardiovascular diseases.

Read the Heart Research Institute's Annual Review and Financial Statement.

Assoc Prof Mary Kavurma is raising awareness of peripheral artery disease, which is now affecting more women than men and also has greater risk of amputation and cardiovascular mortality.

The Heart Research Institute (HRI) has received a visit from MP Mark Coure to help drive awareness of HRI’s world-class research into cardiovascular disease (CVD).

Dr Mary Kavurma was awarded a National Health and Medical Research Council (NHMRC) grant for her research into stimulating blood vessel growth to bypass arterial blockages caused by cardiovascular disease.

HRI sends Prof Roland Stocker the warmest well wishes for his retirement and sincere gratitude for his immense contributions to science, in particular cardiovascular disease research.

Hypertension, also known as high blood pressure, is a common condition. While rates of hypertension have been stable over the past decade, it is a major risk factor for cardiovascular disease.

HRI’s Director of Cardiovascular Research, Professor Shaun Jackson, recently travelled to the UK to hold discussions with scientific and clinical colleagues in the UK as well as members of the British Heart Foundation (BHF) about the global state of cardiovascular disease, its impact on the community, and how we can best fight it.

Our mission is to understand the causes and progression of preeclampsia in pregnancy and examine the links between high blood pressure and cardiovascular disease in women.

Your heart, your health.

Scientists at the Heart Research Institute in Sydney have developed a simple, cheap and efficient way to collect nanoparticles that can be used in the treatment of cancer, cardiovascular disease and Alzheimer’s.

Imagine a future where no-one needlessly dies of cardiovascular disease. Kick off a career with meaning and join HRI, a centre of excellence in medical research.

In Australia, cardiovascular disease continues to take the lives of 22 females every day – killing almost three times more women than breast cancer. Preeclampsia and gestational diabetes developed during pregnancy can significantly increase a woman’s risk of heart disease later in life, but these can be manageable complications if monitored.

The leading cause of death in people with diabetes is cardiovascular disease, with up to 70% of deaths relating to the development of blood clots supplying the heart (heart attack) or brain (ischemic stroke).

Seven of HRI's scientists have been recognised as world leaders in their research fields with the award of prestigious NSW Cardiovascular Research Capacity Building Grants for their work.

Recently, ten bright young researchers from New Zealand took part in a summer scholarship at the HRI to get hands-on experience in our world-class laboratory facilities and to be mentored by leaders in the cardiovascular disease research field. They share their experiences here.

The Heart Research Institute’s annual Awards for Excellence dinner, Illuminate, was recently held to celebrate and recognise some of our most up-and-coming scientists and showcase to our supporters some of the advances we are making in our mission to fight cardiovascular disease.

Grants provide vital contributions to our groundbreaking research.

Congratulations to Professor Shaun Jackson, Director of Cardiovascular Research at the Heart Research Institute and Charles Perkins Centre, The University of Sydney, on receiving the 2018 Ministerial Award for Cardiovascular Research Excellence.

Heart disease is prevalent in Australian women. What can be done about it?

The Heart Research Institute is located across two campuses.

Get a behind-the-scenes look at our cutting-edge research.

Aboriginal health experts at the Heart Research Institute (HRI) are sounding the alarm on atrial fibrillation (AF), a leading cause of stroke, as a pilot study aims to help prevent cardiovascular disease (CVD) in this at-risk population by encouraging people to take a greater role in their own healthcare.

We continue to study potential therapies to boost TRAIL, a novel mediator with marked anti-inflammatory and anti-atherosclerotic properties, in patients with coronary disease.

Inspiring the local community to look after their physical and heart health

HRI and Victor Chang Cardiac Research Institute jointly hosted the 2022 Sydney Cardiovascular Symposium, with the theme “Genomics, Diversity and Equity”, focused on Indigenous Australians and closing the gap in cardiovascular health.

HRI has developed an unprecedented drug design strategy that tailors drugs with fatty acids to minimise side effects.

The Ramaciotti Foundations are investing in research that has the potential to translate into significant improvements in healthcare within the next five years.

Our Distinguished Fellows play a key role in the scientific ecosystem at HRI.

HRI is sponsoring a new Cardiovascular Postgraduate Scholarship under the Sydney Research Awards and Scholarships program.

Exercise has well-documented benefits for decreasing the risk of conditions such as cardiovascular disease, but more than half of Australians are not getting enough physical activity. For many people, the hardest part of exercising is building the motivation to actually start doing it. For others, the expense of a gym or buying special equipment or activewear just isn’t in the budget.

World-leading researcher in atherosclerosis, Dr Tessa Barrett, will lead a new research group at HRI, funded by a prestigious NSW Cardiovascular Elite Postdoctoral Researcher Grant from NSW Health and HRI’s Robert Edward Gough Fellowship.

Investing in tomorrow’s cure

HRI's Rod Halstead has been awarded a Medal of the Order of Australia for services to the community.

The Heart Research Institute’s annual Awards for Excellence dinner, Illuminate, celebrated 30 years of discovery at HRI this year.

Our mission is to understand fundamental mechanisms in molecular and cellular biology and develop more effective treatments for the debilitating conditions associated with vascular complications.

The Heart Research Institute welcomes Dr Ashish Misra as Unit Leader of the Atherosclerosis and Vascular Remodelling Group.

Dr Ashish Misra was recently awarded his second Perpetual IMPACT grant. Dr Misra’s research focuses on improved understanding and potential treatment of atherosclerosis.

HRI reviews the research and provides insights into where future efforts could be made to prevent limb amputation associated with peripheral artery disease.

HRI's Dr Ashish Misra analyses groundbreaking new research into the mechanism of atherosclerotic plaques.

Dr Melissa Farnham has been awarded a Project Grant by the Rebecca L Cooper Foundation for her research investigating the role of the brain in the development of cardiometabolic diseases in people with obstructive sleep apnoea.

Originally from Ireland, Dr John O’Sullivan has been awarded a grant under the NSW Government’s transformative $150 million investment in cardiovascular research.

Peripheral artery disease (PAD) is the third most common form of atherosclerotic disease resulting in gangrene and requiring amputation of limbs.

Congratulations to PhD student Ivy Guan on being awarded the Women in Chemistry Honourable Prize at RACI2022.

Investigations into oxidative stress and endothelial function, as well as the generation of new blood vessels.

The Heart Research Institute (HRI) is an internationally recognised medical research institute that performs groundbreaking cardiovascular research.

Dr Ashish Misra, leader of the Atherosclerosis and Vascular Remodelling Unit at HRI, has been awarded the Perpetual IMPACT grant.

Supporters since 2006

Ross has a family history of heart disease, with his father and his brothers all suffering heart attacks around the age of 58.

Neighbours and committed supporters of HRI

Our mission is to develop new medical devices for cardiovascular research and medicine to improve patient outcomes.

HRI’s Dr Anna Waterhouse joined Professor Paul Weiss from UCLA and Dr Shelley Wickham from The University of Sydney, Schools of Chemistry and Physics, to discuss nanoscience and taking health and medicine to the next level at a public lecture held by Sydney Ideas together with The University of Sydney Nano Institute.

A fundraising appeal by the Heart Research Institute (HRI) has won silver in the Golden Target Awards, run by the Public Relations Institute of Australia (PRIA).

PhD student Paraskevi (Evi) Morris recently spoke at the 69^th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand (CSANZ) 2021.

The Heart Research Institute (HRI) and the Victor Chang Cardiac Research Institute (VCCRI) formally partnered for the second time to host the 2018 Sydney Cardiovascular Symposium, 5–7 December at the Charles Perkins Centre, The University of Sydney.

Congratulations to Dr Ashish Misra, who has been awarded a 2023 NSW Health Senior and Early-Mid Career Researcher Grant in the field of cardiovascular research.

Professor Willem Ouwehand, Professor of Experimental Haematology at the University of Cambridge and at the Sanger Institute speaks to Professor Ben Freedman, Deputy Director Research Strategy and Group Leader at HRI about the state of heart disease research in the UK and the potential for research collaborations.

Smoking is a major risk factor for many chronic diseases and reduces health in general.

Our mission is to identify and gain insights from the genetic and molecular pathways involved in atherosclerotic disease, and exploit these pathways to improve therapies with the aim of eradicating atherosclerotic diseases.

Preeclampsia (high blood pressure during pregnancy) is the leading cause of stillbirths and newborn deaths in Australia. It also doubles a woman’s risk of heart disease and stroke later in life.

HRI's Professor Annemarie Hennessy talks to Channel 7 News about preeclampsia.

The inaugural Mechanobiology Down Under meeting was held at the Bronte Surf Lifesaving Club in Sydney on 3–4 May 2018.

Congratulations to Dr Lining (Arnold) Ju, who was awarded the 2019 Ministerial Award for Rising Stars in Cardiovascular Research.

Heart disease remains the leading cause of death in Australia, according to figures released this week by the Australian Bureau of Statistics (ABS).

Congratulations to Prof Ben Freedman OAM, who has been awarded the prestigious 2023 Ministerial Award for Cardiovascular Research.

Important work to protect people with diabetes from heart disease has been awarded a $2.28m funding boost from the National Health and Medical Research Council (NHMRC).

Dr Jessica Maclean has been awarded a THANZ Scientific & Education Trust Grant to further investigate novel antiplatelet strategies to enhance stroke treatment.

Every day, 23 Australians die from a heart attack. Every year, roughly 55,000 suffer a life-threatening cardiovascular emergency. Like so many, Greg Bridgman never thought it would happen to him.

Molecular Nanorobotics for Health, a project co-led by Dr Anna Waterhouse, Cardiovascular Medical Devices Group Leader at HRI, has been chosen as one of Sydney Nano’s five Grand Challenges in recognition of its potential social, economic and scientific impact.

The Cardiometabolic Disease Group at HRI has published a much-needed review on models of heart failure with preserved ejection fraction (HFpEF).

Dr Xuyu Liu was awarded a 2022 Discovery Early Career Researcher Award as well as a Heart Foundation 2022 Vanguard Grant.

Our mission is to determine the impact of inflammation on the structure and function of the arteries which have a key role in controlling blood pressure.

The Heart Research Institute (HRI) is celebrating 35 years of world-renowned research.

People with heart conditions are at much greater risk of dying if they get COVID-19

Registrations are now open for the virtual Sydney Cardiovascular Symposium, to be held on 9 – 10 December 2021.

Understand safe levels of non-HDL cholesterol and why it's vital for your heart health.

Kerri always suspected there was a link between experiencing preeclampsia with her first child and developing hypertension later in life. She speaks from the heart to share her story.

HRI is delighted to welcome Dr Christopher Stanley as lead of the Microvascular Research Group.

Discover how the cardiovascular system works, its importance for your overall health, and ways to keep it healthy and protect your heart for years to come.

HRI’s Dr Lining (Arnold) Ju has been recognised for his research excellence and public outreach in the Young Tall Poppy Science Awards for his research into heart disease.

Congratulations to two of HRI's leading researchers, Prof Ben Freedman OAM and Assoc Prof Mary Kavurma, who were among the four finalists for the 2023 Australian Cardiovascular Alliance (ACvA) Mentor Award.

Dr Melissa Farnham has been awarded a grant to investigate why people with obstructive sleep apnoea develop high blood pressure and diabetes.

Alan and Jan never expected to lose their happy and active 13-year-old son, Alistair.

HRI's Dr Ashish Misra has received a 2022 Diabetes Australia research grant for his project to identify the mechanisms linking diabetes with atherosclerosis.

Congratulations to Dr Xuyu Liu on being awarded a Drug Discovery Initiative and Cardiovascular Initiative Partnership Grant for his research “A PROTAC-based bioengineering platform for more efficacious antiplatelet drug discovery”.

Australian researchers have developed a simple test to predict diabetes more than a decade before it strikes, a breakthrough that could help ease the impending diabetes epidemic.

Dr Yann Ng has won a 2023 CVRN-VCCRI Research Innovation Grant to further investigate stiff heart failure.

Every 19 minutes, one Australian will suffer a stroke

Professor Leonard Kritharides has recently been welcomed as the new Cardiac Society of Australia and New Zealand (CSANZ) President.

Faye Stephen is a young 53. She goes to the gym and Zumba classes regularly, swims every day, doesn’t drink or smoke, and has been a vegetarian for over a decade.

Summer Scholarships for undergraduate students in their second or third year of University are available at HRI.

A breakthrough by Australian scientists could soon protect tens of thousands of Australian people with diabetes from killer heart disease and strokes.

Heart failure claims a life every 3 hours.

Congratulations to PhD students Manisha Patil and Ivy Guan, finalists in the NSW CVRN Rising Stars Research competition – the HEART Pitch.

HRI’s Dr John O’Sullivan has been awarded a 2020 Future Leader Fellowship for his research into HFpEF, a common form of heart failure.

HRI’s Dr Lining (Arnold) Ju has been awarded a Heart Foundation Future Leader Fellowship as well as the Heart Foundation Paul Korner Innovation Award.

Dr Christopher Stanley’s research focuses on cardiovascular decline seen in sepsis, also known as septic shock – for which there is no clinical treatment.

The Arterial Inflammation and Redox Biology Group, led by Professor Roland Stocker, has published a paper in the prestigious Nature Communications journal.

Read Postdoctorial scientist Dr Yen Chin Koay's thoughts on what attracted her to continue her career in medical research at HRI.

We aim to develop high-affinity ACE2 variants which are capable of scavenging SARS-CoV-2 virus effectively in vivo whilst offering lung- and cardiovascular-protective effects to equivalent levels with respect to current recombinant ACE2 therapeutics.

Here we will examine the effects of long-term, low-dose, colchicine (0.5 mg/day) plus OMT, versus placebo plus OMT, on key vascular and clinical endpoints.

For Katherine Haggarty, hearing about how far research into congenital heart disease has advanced brings a bittersweet joy.

Join today’s research to discover tomorrow’s cure for heart disease.

The cutting-edge liquid chromatography-mass spectrometer system in HRI's Fluxomics Centre will allow researchers to deeply analyse molecular changes in CVD over time.

PhD student Manisha Patil presented the latest research on new avenues to treat peripheral artery disease at the European Society for Microcirculation.

HRI is pleased to welcome Dr Xuyu (John) Liu as Unit Leader.

Get the facts on cholesterol and lipid profile blood tests. Discover what your results mean and how they affect your health.

Matt Shields was not your usual suspect when he had a heart attack aged 40.

“The shock of hitting my chest so hard when I fell was enough to restart my heart and allow me to carry on.”

HRI’s Arterial Inflammation and Redox Biology Group has made an important discovery in preventing peripheral artery disease.

HRI welcomes Dr Mathew Vadas AO as Director of Science Strategy. Dr Vadas is an internationally renowned immunologist and research leader.

Heart Research Institute scientist David Celermajer has been awarded the inaugural Ruthven Blackburn Medal for his distinguished lifetime contribution to Clinical Research.

In HRI’s Atherosclerosis and Vascular Remodelling Group, research assistant Michael Hutton and Dr Ashish Misra have published a review on new targets in the treatment of atherosclerosis.

Dr Lining (Arnold) Ju has been named a Eureka Prize finalist for Outstanding Early Career Researcher in recognition of his excellent scientific research, leadership and engagement.

Our mission is to establish new and innovative approaches to the prevention and treatment of heart disease and stroke – positioning Australia as a leader in the discovery and development of innovative therapies for the treatment of atherothrombotic diseases.

A metabolite linked to red meat and egg-rich diets is not the heart attack and stroke trigger many feared, new Australian research reveals.

Five talented student researchers from New Zealand took part in a summer scholarship at the HRI.

HRI is undertaking several important research projects with collaborators based in New Zealand.

After suffering a heart attack at the age of just 40, Matt is acutely aware that his family history of heart disease could one day impact his son, Clancy. He shares his heartfelt thoughts in a letter to Clancy.

New research may pave the way for determining whether a ketogenic diet may be beneficial in managing blood glucose and complications associated with low blood sugar in diabetes.

HRI and collaborators have published research confirming a clear pattern between the incidence of atrial fibrillation and First Nations peoples.

The Heart Research Institute (HRI) is thrilled to welcome the Cardiovascular Regeneration Group, led by Dr Carmine Gentile, to the team.

Ms Yunjia (Carmen) Zhang received the Best Poster Award for her research focusing on the effects of selenium on atherosclerosis development, at the annual meeting of the Society for Free Radical Research (Australia & Japan).

Dr Steven Wise has been presented the prestigious National Health and Medical Research Council (NHMRC) Marshall and Warren Award.

The Heart Research Institute (HRI) and Victor Chang Cardiac Research Institute (VCCRI) jointly hosted the 2021 Sydney Cardiovascular Symposium, attracting the world’s leaders at the forefront of cardiovascular research.

Dr Jessica Maclean has been awarded a Kanematsu Research Award 2021 from the RCPA Foundation to advance new potential care for stroke sufferers.

Congratulations to Professor Annemarie Hennessy AM, recently named Distinguished Professor by Western Sydney University.

At the age of 5, Brad was diagnosed with Type 1 diabetes. He has faced a lifetime of health complications, including losing both his legs below the knee. And yet remarkably, he has remained incredibly positive through it all.

Last week, an exciting event was held at The University of Sydney to celebrate the collaboration between the Heart Research Institute (HRI) and Charles Perkins Centre (CPC).

A smart phone app that can detect heart abnormalities in just 30 seconds is being trialled in Aboriginal and Torres Strait Islander communities across Australia.

Phil Dobrincic is a young and active 50-something year old. A devoted husband to Jenny and dedicated father of four, Phil has enjoyed fatherhood, its challenges and rewards, for more than 20 years.

HRI welcomed Summer Scholars from both Australia and New Zealand to experience a research career at HRI for seven weeks.

Heart Research Institute is helping to bring together world-leading scientists to solve some of the most pressing issues affecting the hearts of people around the world.

Professor David Celermajer, cardiologist and Clinical Research Group Leader at the Heart Research Institute, answers some common questions around mRNA COVID-19 vaccines and their potential to cause pericarditis and myocarditis.

Four years ago, when Jason first felt a squeezing pain across his chest while cycling around Olympic Park in Sydney, he dismissed it as a pulled muscle. He got in his car and drove home.

A young Sydney scientist has invented a body patch that breathes life into dead tissue following a stroke or heart attack, dramatically improving a patient’s chance of full recovery.

This project investigates the transformation of a direct thrombin inhibitor into a photo-responsive therapy for stroke, with the aim to precisely control local anticoagulation using two-photon excitation lasers.

New research has shown how novel eHealth tools used in rural Australian general practices are helping to reduce gaps in screening and treatment for atrial fibrillation (AF) in people over 65 years of age.

The Heart Research Institute (HRI) is collaborating with the University of Manchester, UK on research that aims to develop a deeper understanding of sepsis to prevent hypotension.

“Is that where the doctor fixed your heart, Nana?” It was an emotional conversation for Jean to have with her granddaughter, as they looked at Jean’s new scars on her chest. Jean’s heart attack had come out of the blue and resulted in a triple bypass.

Lifestyles have become more sedentary, and this inactivity can negatively impact health.

Find out more about the human heart – the main organ of your circulatory system – and its essential role in the body.

Exercise is one of the best ways to boost your heart health and overall wellbeing, but choosing one to suit your goals and abilities can be daunting. Here are some comparisons of different types of exercise to help you make the best choice for you.

Discover how your age affects your blood pressure. Find out the normal range of blood pressure by age to maintain good health and prevent disease.

HRI is conducting a collaborative research project investigating the mechanisms of platelet hyperactivity in diabetes with Dr Maggie Kalev-Zylinska, University of Auckland.

Here are our top 10 tips to help you stick to New Year's resolutions for the long term.

HRI is an internationally recognised medical research institute with global collaborations.

The type and amount of exercise you should do changes as you age, so follow this simple guide for tips on the right type of exercise for your stage of life.

Scarlett was just 13 when she had two cardiac arrests and went into end stage heart failure. Her parents were told a heart transplant was the Sydney school girl's only chance of survival. This is her story.

Heart experts at HRI are calling for better screening for Indigenous Australians to protect them from high and growing rates of a common heart condition linked to deadly strokes.

An exciting opportunity for NZ postgraduate students considering a career in medical research.

Dr Chris Stanley has been awarded a 2022 Ramaciotti Health Investment Grant for his research exploring the treatment of hypertension.

“Your daughter needs open heart surgery.” For Basil and Susan Mourtos, these words were the start of their worst nightmare become reality.

It's said that drinking red wine is good for the heart – but does alcohol increase heart rate and blood pressure?

Harness the power of your core business and your employees to prevent death and suffering from heart disease.

The Heart Research Institute (HRI) has secured more than $4.3 million of funding with the announcement of this year’s National Health and Medical Research Council (NHMRC) Ideas and Development Grants.

Dr Melissa Farnham was awarded a Diabetes Australia research grant for her work investigating the protective effects of a ketogenic diet against severe hypoglycaemia that frequently occurs in people with diabetes.

Scientists at HRI and The University of Sydney have made new heart failure discoveries in an innovative world-first project examining cryo-preserved human hearts.

HRI is delighted to announce that world-leading cardiovascular expert Professor Andrew Coats AO is joining the Institute as Scientific Director.

Bruna never got sick and rarely took a day off work, so when she experienced indigestion at work, she initially ignored it.

A foundational partnership

Delegates from across Australia gathered for the 2023 Sydney Cardiovascular Symposium, an annual event co-hosted by the Heart Research Institute (HRI) and the Victor Chang Cardiac Research Institute (VCCRI).

People often don’t think about cholesterol levels until there is cause to wonder, such as after a blood test check-up. While genetics can influence cholesterol levels to a degree, the foods we eat also play a part.

Congenital heart disease affects up to one in every 100 babies. I was that one baby. My name is Cara. I’m 35, and I’ve had five open heart surgeries.

With all the choices out there today and mixed messages on what is the absolute best type of exercise, it can be daunting deciding which exercise will win your heart and give you the best bang for your buck – financially and with regard to fitness outcomes.

A drug used to treat arthritis has been found to clear clogged arteries in heart attack survivors, world-first Australian research shows.

This year during NAIDOC Week, HRI took the opportunity to learn about First Nations cultures and histories, and to celebrate the oldest, continuous living cultures on earth.

In a world-first, researchers at the Heart Research Institute and The University of Sydney believe they’ve found evidence that women who smoke while pregnant affect their child’s cardiovascular health for years to come.

Read Dr Xuyu Liu's video transcript where he talks about his career to date and gives advice about working in medical research.

Liesl may only have half a working heart, but she hasn’t let that stop her. In fact, it inspired her to help others like her.

Congratulations to Dr John O’Sullivan on being awarded a Vanguard Grant for his research into “stiff” heart failure.

Find out what a Mediterranean diet is, how it can help your heart health and overall wellbeing, and easy ways to incorporate it into your diet.

HRI is on the cusp of developing a drug to save people from deadly strokes using a common Australian bush tick.

Getting enough sleep is important for your health. If you suffer from sleep problems, here’s how to get a good night’s sleep.

HRI has launched an international drug discovery project investigating the development of a photo-responsive therapy for ischaemic stroke.

Type 2 diabetes (T2D) is a global epidemic.

The Heart Research Institute (HRI) is delighted to welcome the Djurali Centre for Aboriginal and Torres Strait Islander Health Research and Education to the team.

Talented Heart Research Institute (HRI) bioengineer Dr Steven Wise is taking up an exciting opportunity to further his innovative research program with the HRI’s close collaborative partner The University of Sydney (USYD).

The Thrombosis Group at HRI has been awarded an OHMR award for a PhD Scholarship. The award will support PhD student Cameron Trought in stroke research.

HRI is establishing the Congenital Heart Alliance of Australia and New Zealand (CHAANZ) Congenital Heart Disease Registry, a comprehensive NZ registry of demographic and clinical data from cohorts of paediatric and adult cases of CHD from sites across New Zealand.

Distinguished Professor Annemarie Hennessy AM is celebrating 20 years at HRI as Vascular Immunology Group Leader this year.

Obesity and being overweight is a condition where a person carries excessive body fat that presents a risk to health.

Linda was born with congenital heart disease and has undergone four open heart surgeries. But that hasn't stopped her from working on her cattle and crop farm, and raising her two boys.

A high intake of vegetables (raw or cooked) is the cornerstone of a healthy diet – you literally can’t eat well without them.

To help you stay ahead of heart health problems, here are some heart health mistakes you should keep in mind with solutions to help avoid them.

Laura experienced both preeclampsia and gestational diabetes while pregnant with twins. Keen to help other first-time mothers, Laura shares her story.

The Heart Research Institute’s annual Awards for Excellence dinner, Illuminate, celebrated and recognised some of our most up-and-coming scientists, as well as the contributions of women to medical research.

Here are nine common misconceptions about exercise and what research actually tells us.

There are many misconceptions surrounding type 2 diabetes, especially in relation to diet. We’ve broken down some common myths and provide tips for new habits to start putting into action.

A three-year world-first study by the Heart Research Institute (HRI) has found that a natural chemical found in broccoli could prevent and treat one of the nation’s biggest killers.

Aged just 38, Phil had no reason to think the aches and pains he had been suffering were anything sinister. Here is his story in his own words.

Dr Yen Chin Koay provides an update on spending six months investigating stiff heart failure in Prof Christopher Loughrey’s lab in Glasgow, Scotland.

Among the many ways COVID-19 can damage our health, the virus can affect the heart and directly cause a range of heart complications.

The Heart Research Institute (HRI) has received a gift of $400,000 from the Vasudhara Foundation to support the work of esteemed cardiologist and researcher, Prof David Celermajer AO.

Assoc Prof Simone Schoenwaelder was awarded a Brain Foundation Research Gift for her work ‘Identification of New Approaches for the Treatment of Stroke’. These Gifts are awarded to applicants on the scientific quality and significance and/or innovation of their research.

Obstructive sleep apnoea (apnea) is a sleep disorder where breathing repeatedly stops and starts.

Dr Melissa Farnham answers some common questions about sleep apnoea, its symptoms, differences between men and women, and what we can all do about it.

Due to the popular low-fat diets of the 80s and 90s, combined with the even more popular high-fat diets of the 2000s (Atkins and later paleo), many people are confused by this hotly debated nutrient: fat.

Enjoy the career benefits of work and study with international leaders in the field of cardiovascular research.

HRI has discovered cruciferous veg like Brussels sprouts and broccoli can help dissolve blood clots and improve the performance of clot-busting drugs, which could help treat stroke.

The brain is an essential, complex organ. It controls the functions and processes that regulate the body.

Our mission is to discover targets for new and safe anti-thrombotics, and improve on current treatments.

When Kelsey was 25, her beloved dad, ‘Chrisso’ had a fatal cardiac event, leaving the close-knit family completely devastated. Now, the Melbourne paramedic and critical care nurse is on an incredible mission to save as many lives as she can in her dad’s name.

Stroke claims more than 10,000 lives in Australia each year

HRI has launched an international research project investigating new therapeutic strategies for stiff heart failure.

“My heart condition is important to me as it’s something I have, but it’s not who I am,” says 22-year-old Taylor.

Stress can affect the heart and your overall wellbeing. Here are some tips to better manage it.

An HRI study is investigating whether a Mediterranean diet for pregnant women can positively impact their babies’ heart development.

The impact of COVID long term is yet to be seen, and more data about “long COVID” needs to be gathered, but here’s what we know so far.

Marjorie Doyle was born with a complex form of congenital heart disease in 1955. She survived against the odds, and now she wants to give back and help others.

About one in four women may develop atrial fibrillation after menopause, with stress and insomnia being leading factors, according to a new study.

After trying to conceive for seven years, Samara was devastated to discover her baby had several heart defects. Riley had her first open heart surgery two weeks after she was born, and at nine weeks, she suffered a cardiac arrest.

While salt reduction is a main way to help reduce blood pressure, there are other important nutritional factors to consider when trying to reduce blood pressure through dietary changes.

As HRI celebrates its 35^th anniversary, we spoke to a few of our alumni about their fondest memories at the Institute.

HRI's Prof Ben Freedman is taking part in a health screening program for atrial fibrillation and high blood pressure to improve Indigenous health.

A nutrition label has many different aspects, and trying to navigate through all the information can be a challenge. Here’s a breakdown of the nutrition information section of the label and what it means.

Throughout her pregnancy, Renee was assured that everything was okay, even though she knew something wasn’t quite right. From there, problems developed quickly.

When Elle Pendrick was told she needed her fifth open heart surgery at age 33, she was completely numb and shell-shocked.

People born with half a heart or single-ventricle congenital heart disease (Fontan-CHD) are now living longer than ever before, thanks to advances in medicine and technology.

Every year, 55,000 Australians suffer a stroke, and many are left with life-changing disabilities. A macroscope could help change that.

Setting your children up with a good foundation of eating fresh, whole foods is one of the best ways you can help care for their current and future health.

The Heart Research Institute (HRI) celebrated International Women’s Day (IWD) and gender equity with an inspiring seminar featuring three amazing women.

Anna Grocholsky, Director of Commercialisation at HRI, works to identify and develop scientific discoveries at HRI that have commercial potential.

Nutrition plays a vital role in protecting the health of your heart. It can reduce your risk of having a cardiac event, help you recover from one and reduce your risk of it happening again. Here’s what you should keep in mind.

A new paper on how biomechanical thrombus growth is mediated has been published by the HRI team led by Prof Shaun Jackson and Dr Arnold (Lining) Ju in Nature Materials.

Clarissa is a twin and she was also born with complex congenital heart disease. She is a warrior and an inspiration to us all at HRI. This is her story.

Born with a hole in his heart, Kelvin nearly didn’t survive open heart surgery at just seven years old.

Dr Sanjay Patel, Group Leader at the Heart Research Institute, has been awarded a highly prestigious 2016 Ramaciotti Grant to pursue his work developing a cost-effective therapy to prevent heart attack and stroke.

A target of 10,000 steps a day is often recommended, and it has been shown to improve heart health. Find out where this number came from and how to achieve it.